Benjamini–Hochberg FDR control under correlated Gaussian tests

Does ordinary Benjamini–Hochberg testing control false discovery rate at its nominal level for correlated two-sided Gaussian p-values? Independence and positive regression dependence provide known positive settings; arbitrary Gaussian correlation is the question.

Why it matters and what counts as progress

Why it matters: A dependent Gaussian example would delimit false-discovery control beyond independence and positive regression dependence.

What counts as progress: Prove control under broader dependence assumptions or give a specified Gaussian model with rigorously excessive false discovery rate.

How the problem developed

  1. 1995 · Theorem [1]

    Yoav Benjamini and Yosef Hochberg Introduced the step-up procedure and proved false discovery rate control under independent test statistics.

  2. 2001 · Partial result [2]

    Yoav Benjamini and Daniel Yekutieli Showed BH control under positive regression dependence and gave a harmonic-factor modification valid under arbitrary dependence.

  3. 13 Jul 2026 · Reported claim [3]

    Edgar Dobriban, with GPT-5.6 Pro Reported a correlated two-sided Gaussian factor model where BH exceeds nominal FDR 0.01, with a rigorous interval-arithmetic lower bound above 0.0104.

AI contribution

The Benjamini--Hochberg Procedure Can Fail to Control the FDR for Correlated Two-Sided Gaussian Tests

Edgar Dobriban

In a specified three-block Gaussian factor model with 96N true nulls and 4N nonnulls, ordinary Benjamini–Hochberg testing at level 0.01 has false discovery rate greater than 0.0104 for all sufficiently large N when applied to correlated two-sided Gaussian p-values.

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Sources

  1. Benjamini and Hochberg, Controlling the false discovery rate
  2. Benjamini and Yekutieli, The control of the false discovery rate in multiple testing under dependency
  3. Dobriban, The Benjamini–Hochberg Procedure Can Fail to Control the FDR for Correlated Two-Sided Gaussian Tests
  4. Benjamini–Hochberg FDR under correlated Gaussian tests
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